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This review tries to address this issue while providing the fundamental principles of these techniques, summarizing the core mathematical principles and offering practical guidelines on tackling commonly encountered problems while running DLS and ZP measurements. Additionally, there is little literature available in drug delivery research which offers a simple, concise account on these techniques. As both DLS and ZP have emerged from the realms of physical colloid chemistry – it is difficult for researchers engaged in nanomedicine research to master these two techniques.
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Unfortunately, on practical grounds plenty of challenges exist regarding these two techniques including inadequate understanding of the operating principles and dealing with critical issues like sample preparation and interpretation of the data. Robust, dustproof and waterproof they measure particles in the size range 50-6000 µm with velocities from 0.
![malvern zetasizer air touching probe malvern zetasizer air touching probe](https://i.ytimg.com/vi/WMaj_9d9xbY/maxresdefault.jpg)
DLS (dynamic light scattering) and ZP (zeta potential) measurements have gained popularity as simple, easy and reproducible tools to ascertain particle size and surface charge. Another process tool from Malvern Panalytical, Parsum probes use spatial filter velocimetry for particle size measurement and particle velocity inline. sent to one of Malvern specialist and my colleagues are it touch with him. Determination of particle size and surface charge of NPs are indispensable for proper characterization of NPs. Roland Kerr DLS doesnt need the optical properties for an intensity size. Malvern Instruments has introduced a new, improved disposable folded capillary cell for use in its Zetasizer Nano particle and molecular characterization. Adequate characterization of NPs (nanoparticles) is of paramount importance to develop well defined nanoformulations of therapeutic relevance.